A frustrated Manhattan literary editor, Peter Loew (Nicolas Cage), meets a mysterious woman (Jennifer Beales). During a passionate night of lovemaking, the woman bites him on the neck, drawing blood. When she disappears the next morning, Peter becomes convinced that she was a vampire and that he's become one too. Despite the protests of his psychiatrist (Elizabeth Ashley), he loses himself to pressure of everyday life, and begins to act the role of a creature of the night.

There is a serial killer terrorizing Manhattan. Mayor Rod Steiger wants it to stop now. The agitated mayoral assistant (Harvey Keitel) calls on his former--brilliant, nonconformist--cop brother (Kevin Kline) to return to the force and handle the case. Kline agrees, for a price: a date with Keitel's gorgeous wife (Susan Sarandon). Kline amasses details on the killer and calculates a pattern that allows him to predict the killer's next crime, which will take place in the labyrinthine corridors of a major skyscraper. Screenplay by John Patrick Shanley (MOONSTRUCK).